Structure – Bioactivity Relationship in Cyclic Peptoids: An Overview

Cyclic N-substituted glycines oligomers, also known as cyclic peptoids, constitute a promising class of novel peptidomimetics, capable simulating bioactive effectors with enhanced proteolytical stability and cell permeability crucial bonuses. The macrocyclic constraint, essential for the induction stable secondary structures, determines biomimetic potential such molecules, which act antimicrobials, cytotoxic agents, siderophores, glycosidases inhibitors so on. bioactivity can be either attributed to core (especially chelation) or side-chains (when endowed specific groups pharmacophores). structure-bioactivity correlations emerging this based on study conformational order morphology backbone architecture, unravel interesting avenues rational design more effective cyclooligomeric biomimics.